Título: “Hyaluronan in Immune Responses: A complex balancing act of structure, function, location and context”

Palestrante: Dr. Rashmin Savani (Universidade do Texas - EUA)
Chief, Division of Neonatal-Perinatal Medicine e Diretor do Center for Pulmonary & Vascular Biology University of Texas Southwestern Medical Center.

Data: 18 de outubro de 2019
Horário: 9h30
Local: Auditório Leopoldo e Meis - CCS/UFRJ

Resumo: Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell contextspecific signaling. Therapeutic approaches based on hyaluronan biology have been successful and look promising in the future with new technologies being developed.